Rheumatoid arthritis : Looking Beyond Rheumatoid Factor
نویسندگان
چکیده
762 IntroductIon Rheumatoid arthritis (RA) is a chronic crippling disease that causes significant morbidity and even mortality. The etiology is not known and hence the diagnosis is based on the typical clinical picture of inflammatory symmetrical polyarthritis supported by imaging and serological investigations. Among the serological investigations, rheumatoid factor (RF) is the most widely used. Rheumatoid factor (RF) is an IgM/IgG/IgA autoantibody directed against the Fc portion of human IgG. Commonly it is the IgM RF that is assayed either by latex agglutination or nephelometry. Even though it is present in 60 to 80% of patients with RA, its diagnostic role is limited because of low specificity. It is present in several diseases including autoimmune connective tissue diseases such as primary Sjogren’s syndrome (SS), systemic lupus erythematosus (SLE), essential mixed cryoglobulinemia (EMC), infectious diseases like tuberculosis, leprosy and in elderly healthy individuals.1
منابع مشابه
Differential Expression of Rheumatoid Factor-Associated Cross-Reactive Idiotypes in Iranian Seropositive and Seronegative Patients with Rheumatoid Arthritis
High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...
متن کاملComparative Measurement of Rheumatoid Factor in Serum and Synovial Fluid of Rheumatoid Arthritis Patients by ELISA and Latex-Agglutination Test
Rheumatoid factors (RF) are autoantibodies with specificity for the Fc portion of human IgG. Production of RF is a characteristic feature of rheumatoid arthritis (RA) and is detectable in high titer in about 90% of these patients. In this study, we measured total IgM, IgA, IgMRF and IgARF in serum and synovial fluid of 45 RA patients by ELISA and the results were compared with those obtained b...
متن کاملCorrelation between anti-nuclear antibodies (ANA), rheumatoid factor (RF), anti-cyclic citrullinated peptides antibodies (Anti-CCP) and percentage and type of pulmonary involvement in patients with rheumatoid arthritis, Booali Hospital Tehran (2016-2
Background: Controlling the pulmonary involvement, as one of the most common extra-articular consequences in rheumatoid arthritis (RA), can improve the life quality and survival rate of patients. This study aimed to evaluate the correlation between disease-related inflammatory factors and the severity and type of lung involvement in patients, which is a practical step toward early detection and...
متن کاملارزیابی آزمون VDRL در مبتلایان به آرتریت روماتوئید
Background and Aim: Rheumatoid arthritis is a systemic, chronic and inflammatory disease. It is characterized by the symmetric synovitis of the articules of the extremities. Its major cause is unknown.Immunological factors including Rheumatoid factor (RF) are considered as more confirming Cause. To date Rheumatoid factor is consisted of many antibodies which are produced against the constant r...
متن کاملCutaneous manifestations in patients with rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with different extra-articular manifestations. Among those extra-articular manifestations, there are significant cutaneous manifestations which may result in first admission to a dermatologist. In this article some specific and non-specific skin lesions of RA such as rheumatoid nodules, exacerbated nodules, rheumatoid vascu...
متن کامل